Thiotepa classification
Webthiotepa General High Alert Medication: This medication bears a heightened risk of causing significant patient harm when it is used in error. Pronunciation: thye-oh- tep -a To hear audio pronunciation of this topic, purchase a subscription or log in. Trade Name (s) Tepadina Ther. Class. antineoplastics Pharm. Class. alkylating agents WebNov 1, 2024 · Thiotepa is a synthetic product with antitumor activity. The chemical name for Thiotepa is Tris(1-aziridinyl)phosphine sulfide. Thiotepa has the following structural formula: Thiotepa, USP has the molecular formula C 6 H 12 N 3 PS, and a molecular …
Thiotepa classification
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WebThiotepa suppresses cell growth and division and was introduced in 1953 for use in cancer chemotherapy to treat lymphoma and a vari-ety of solid and soft-tissue tumors. It was commonly used in cancer therapy until the early 1970s (only 3 kg of thiotepa was used in … WebJun 30, 2024 · Print SmPC information 1. Name of the medicinal product 2. Qualitative and quantitative composition 3. Pharmaceutical form 4. Clinical particulars 5. Pharmacological properties 6. Pharmaceutical particulars 7. Marketing authorisation holder 8. Marketing authorisation number (s) 9. Date of first authorisation/renewal of the authorisation 10.
WebSep 17, 2024 · A composition according to the present invention can very effectively prevent, ameliorate, or treat gastric cancer, specifically intractable gastric cancer, by screening a subject with suitable generic characteristics for a drug capable of suppressing caveolin-1-mediated endocytosis, and administering the drug into the screened subject. WebMedscape - Indication-specific dosing for tespa, Thioplex (thiotepa), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.
WebDec 5, 2024 · Tepadina belongs to a class of drugs called Antineoplastics, Alkylating. It is not known if Tepadina is safe and effective in children. ... Thiotepa given by the intraperitoneal (IP) route was teratogenic in mice at doses ≥ 1 mg/kg (3.2 mg/m 2), approximately 8-fold less than the maximum recommended human therapeutic dose (0.8 … WebThiotepa is in a class of medications called alkylating agents. It works by slowing or stopping the growth of cancer cells in your body. How should this medicine be used? Thiotepa comes as a powder to be mixed with liquid to be injected intravenously (into a …
WebTriethylenephosphoramide (TEPA), a metabolite of thiotepa, is detected in plasma 5–10 minutes after intravenous injection, and persists longer in plasma with a half-life of 3–21 hours. Both thiotepa and TEPA penetrate …
WebThiotepa was intraperitoneally administered to two groups of 15 male and 15 female ras H2 mice, 7–9 weeks of age, at doses of 1 and 2 mg/kg bw, 3 times per week for 24 weeks. Two similar groups of wild-type mice were … mixing bowl restaurant vernon njWebApr 4, 2011 · Thiotepa ≥300 mg/m 2 has been classified as a high-risk emetogen in this guideline (see the first recommendation). In alignment with the desire to avoid gaps in the dose range of agents included in this guideline, thiotepa in lower doses of was classified as a low-risk emetogen based on its classification in the COG Supportive Care Guidelines ... mixing bowl picturesWebSep 21, 2024 · Generic name: thiotepa [ THYE-oh-TEP-a ] Brand names: Tepadina, Thioplex Dosage form: injectable powder for injection (100 mg; 15 mg; 30 mg) Drug class: Alkylating agents Medically reviewed by Drugs.com on Sep 21, 2024. Written by Cerner Multum. … ingrid and isabel maternity topsWebFeb 17, 2024 · Excretion Urine (<2% of thiotepa dose; <11% of TEPA) Half-Life Elimination Terminal: Pediatrics (5 mg/kg IV dose): Thiotepa: 1.7 hours; TEPA: 4 hours Adults (20 mg to 250 mg/m 2 IV dose): Thiotepa: 1.4 to 3.7 hours; TEPA: 4.9 to 17.6 hours Protein Binding ~10% to 20% Use in Specific Populations Special Populations: Renal Function Impairment ingrid and isabel maternity shortsWebIn a retrospective analysis in pediatric patients (n = 25; median age, 10 years; range, 5 to 16 years; human leukocyte antigen (HLA)-identical sibling donor, 100%) with class 3 beta-thalassemia, no patients experienced acute or late graft rejection following treatment with thiotepa, busulfan (weight-based IV dosing for 4 days (16 total doses ... ingrid and isabel maxi dressWebJan 4, 2024 · A comprehensive guide to side effects including common and rare side effects when taking Thiotepa (Thiotepa Injection) includes uses, warnings, and drug interactions. Drugs & Vitamins Drugs A-Z Generic Drugs A-Z Drugs … ingrid and isabel shirred maternity dressWebMar 20, 2024 · TEPADINA (thiotepa) is an alkylating drug indicated: ()To reduce the risk of graft rejection when used in conjunction with high-dose busulfan and cyclophosphamide as a preparative regimen for allogeneic hematopoietic progenitor (stem) cell transplantation (HSCT) for pediatric patients with class 3 beta-thalassemia. ingrid and isabel maternity skirt